SIR4 (YDR227W)A permutation based statistical method (PBM5) ranks this transcript 824 among all S. cerevisiae genes based on its periodicity and magnitude of oscillation among five data sets. Using an arbitrary cutoff of 1000, this transcript is considered periodic. Its weighted average peak occurs at 50% of the cell cycle, where we use the M/G1 boundary as 0%. For other landmark peak times see this figure. For further details, please visit our website at http://www.fhcrc.org/science/labs/breeden/cellcycle.
In the first three data sets, data points that have been flagged as suspect are plotted in red.
If you use these data in your research, please cite the following papers. The alpha 30, alpha 38 and alpha 26 data sets are described inT. Pramila, W. Wu, W. S. Noble and L. L. Breeden. "The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S phase gap in the transcriptional circuitry of the cell cycle." Genes and Development. 20(16):2266-2278, 2006.The alpha and cdc15 data sets are described inP. T. Spellman and G. Sherlock and M. Q. Zhang and V. R. Iyer and K. Anders and M. B. Eisen and P. O. Brown and D. Botstein and B. Futcher. "Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization." Mol Biol Cell. 9(12):3273-97, 1998.The cdc28 data set is described in"A genome-wide transcriptional analysis of the mitotic cell cycle." R. J. Cho, M. J. Campbell, E. A. Winzeler, L. Steinmetz, A. Conway, L. Wodicka, T. G. Wolfsberg, A. E. Gabrielian, D. Landsman, D. J. Lockhart and R. W. Davis. Molecular Cell. 2(1):65-73, 1998.Please direct inquiries to Linda Breeden (email@example.com) or Bill Noble (firstname.lastname@example.org).