Pretargeted radioimmunotherapy for the treatment of Multiple Myeloma & B cell malignancies
Anti-CD38 and anti-BCMA bispecific antibodies deliver targeted radioimmunotherapy and avoid systemic toxicity.
- Stage: Preclinical in vivo
- Type: Therapeutic
- Categories: Hybridoma / Antibody, Immuno Oncology, Target
Pretargeted radioimmunotherapy (PRIT) differs from conventional RIT in that a nonradioactive bispecific targeting antibody is first administered allowing for localization in tumor sites. Then a low molecular weight radioactive moiety (such as Y90) is added facilitating rapid tumor penetration, capture, and retention of Y90 by the pretargeted antibody. The rapid clearance of unbound radioactive molecules greatly decreases radiation absorption by healthy tissues. Multiple myeloma (MM) is an excellent candidate for PRIT due to the high degree of target expression (CD38 or BCMA) compared to normal myeloid and lymphoid cells. The Green Lab has constructed bispecific antibodies which target either CD38 or BCMA and have demonstrated their superiority over prior PRIT approaches. In preclinical studies, the CD38 PRIT clinical candidate cured over 75% of mice vs. 5% cured in the control group and showed similarly promising results in non-Hodgkin lymphoma.